Convenient STR Dosing & Administration

Dosing & Administration

 

The smallest darunavir coformulation available.

One tablet, once daily with food.

Drugs that are contraindicated

Alpha 1-adrenoreceptor agonist alfuzosin
Anticonvulsants carbamazepine, phenobarbital, phenytoin
Anti-gout colchicine in patients with renal or hepatic impairment
Antimycobacterial rifampin
Antipsychotics lurasidone, pimozide
Cardiac Disorders dronedarone, ivabradine, ranolazine
Ergot derivatives dihydroergotamine, ergotamine, methylergonovine
GI motility agent cisapride
Herbal product St. John’s wort
Hepatitis C direct-acting antiviral elbasvir/grazoprevir
Lipid modifying agents lomitapide, lovastatin, simvastatin
Opioid Antagonist naloxegol
PDE-5 inhibitor sildenafil for treatment of pulmonary arterial hypertension
Sedative/hypnotics midazolam (oral), triazolam

Coadministration not recommended*

Anticoagulant rivaroxaban
Anticonvulsants eslicarbazepine, oxcarbazepine
Antifungal voriconazole
Antimycobacterials rifapentine, rifabutin
Systemic/inhaled/nasal/ophthalmic corticosteroids betamethasone, budesonide, ciclesonide, dexamethasone, fluticasone, methylprednisolone, mometasone, triamcinolone
Hepatitis C direct-acting antivirals glecaprevir/pibrentasvir, simeprevir
Immunosuppressant/neoplastic everolimus, irinotecan
Inhaled beta agonist salmeterol
PDE-5 inhibitor avanafil
Platelet aggregation inhibitor ticagrelor

*Recommendations are based on drug interaction trials conducted with components of SYMTUZA®, as individual agents or in combination, or are predicted interactions.

GI=gastrointestinal; PDE-5=phosphodiesterase type 5; STR=single-tablet regimen.

Reference: 1. SYMTUZA® [package insert]. Titusville, NJ: Janssen Therapeutics, Division of Janssen Products, LP; 2019.