DHHS Guidelines: Rapid Initiation
Selected Sections From the DHHS Guidelines: Rapid Initiation
ART REGIMENS RECOMMENDED FOR RAPID INITIATION1*
Boosted DRV with FTC or 3TC plus TAF or TDF†
- Boosted DRV has a high barrier to resistance and a low rate of treatment-emergent resistance
DTG with FTC or 3TC plus TDF or TAF
- DTG/3TC is not recommended in rapid initiation
BIC/TAF/FTC
- Clinical data and experience defining the BIC barrier to resistance are relatively limited at this time
- Because of insufficient data in pregnancy, BIC/TAF/FTC should not be used in people who are pregnant
*A sample for genotypic testing should be sent before initiation of ART.1
†DRV/c is not recommended for use in pregnancy.1,2
3TC=lamivudine; ART=antiretroviral therapy; BIC=bictegravir; DHHS=Department of Health and Human Services; DRV=darunavir; DRV/c=darunavir/cobicistat; DTG=dolutegravir; FTC=emtricitabine; TAF=tenofovir alafenamide; TDF=tenofovir disoproxil fumarate.
References: 1. Department of Health and Human Services. Guidelines for the use of antiretroviral agents in adults and adolescents with HIV. Updated January 20, 2022. Accessed March 8, 2022. https://clinicalinfo.hiv.gov/en/guidelines/adult-and-adolescent-arv/whats-new-guidelines 2. SYMTUZA® [package insert]. Titusville, NJ: Janssen Therapeutics, Division of Janssen Products, LP.